Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.16 (overall 0.12) | 0.16 |
| cell type Human Protein Atlas | cell type enhanced, including other brain neurons; strongest in thyrotrophs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 20 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2359
Sealed predictions
- SYT10 in dopamine neurons, braak-0.45 (p 0.224) → +0.61 (p 0.078)receipt 2367
Swarm cases
receipt 2367: SYT10 in dopamine neurons, braak
- power
- full sample +0.09 (p 0.722, n 18), 95% CI -0.39 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.715, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.709, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.25, sign flips 2; without severely affected donors +0.09 (p 0.722, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SYT10 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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