Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in brain excitatory neurons (58 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 23 Parkinson's papers of 695 | 0.58 |
| pathways Reactome | 3 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 5269
Sealed predictions
- SYN1 in dopamine neurons, braak+0.37 (p 0.323) → -0.29 (p 0.449)receipt 5277
Swarm cases
receipt 5277: SYN1 in dopamine neurons, braak
- power
- full sample +0.01 (p 0.956, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.01 (p 0.962, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.05 (p 0.847, n 18). could be the mix.
- skeptic
- leave-one-out range -0.09 to +0.16, sign flips 8; without severely affected donors +0.01 (p 0.956, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SYN1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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