Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

SVEP1

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

translation score 0.47, read 2026-11-01; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in fibro-adipogenic progenitors0.75
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 17099

Sealed predictions

  1. SVEP1 in dopamine neurons, braak-0.47 (p 0.207) → -0.32 (p 0.407)receipt 17107
  2. SVEP1 in oligodendrocytes, braak+0.26 (p 0.498) → -0.45 (p 0.227)receipt 17106

Swarm cases

receipt 17107: SVEP1 in dopamine neurons, braak

power
full sample -0.28 (p 0.261, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.25 (p 0.310, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.393, n 18). could be the mix.
skeptic
leave-one-out range -0.41 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.261, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SVEP1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 17106: SVEP1 in oligodendrocytes, braak

power
full sample -0.08 (p 0.761, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.05 (p 0.840, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.09 (p 0.709, n 18). could be the mix.
skeptic
leave-one-out range -0.18 to +0.06, sign flips 2; without severely affected donors -0.08 (p 0.761, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SVEP1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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