Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

SULT1A3

sulfotransferase family 1A member 3

translation score 0.61, read 2026-10-27; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced in astrocytes (7 nCPM)1.00
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		2 Parkinson's papers of 1740.85
pathways
Reactome		3 pathways; mostly protein handling0.90
proposal for SULT1A3, translation score 0.61

Knock down and overexpress SULT1A3 in astrocytes; measure proteasome activity and the load of ubiquitinated protein and α-synuclein uptake and degradation, and dopamine neuron survival in co-culture.

Cell type
astrocytes
Direction
Both arms: public data does not say which way helps.
Molecular readout
proteasome activity and the load of ubiquitinated protein
Functional readout
α-synuclein uptake and degradation, and dopamine neuron survival in co-culture
Rule-out
If neither arm moves proteasome activity by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of SULT1A3 in iPSC-derived midbrain astrocytes; n = 3 differentiations; readouts: proteasome activity and the load of ubiquitinated protein; α-synuclein uptake and degradation, and dopamine neuron survival in co-culture. Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. SULT1A3 in dopamine neurons, braakn/a → n/areceipt 11705
  2. SULT1A3 in astrocytes, braakn/a → n/areceipt 11704

Swarm cases

receipt 11705: SULT1A3 in dopamine neurons, braak

cell type
SULT1A3 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SULT1A3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 11704: SULT1A3 in astrocytes, braak

cell type
SULT1A3 is not measured in astrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SULT1A3 in astrocytes.

case closed: nothing better to follow up.

Receipts

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