Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 55 Parkinson's papers of 13,812 | 0.47 |
| pathways Reactome | 31 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 4735
Sealed predictions
- STAT1 in dopamine neurons, braak-0.55 (p 0.121) → +0.34 (p 0.369)receipt 4743
Swarm cases
receipt 4743: STAT1 in dopamine neurons, braak
- power
- full sample +0.03 (p 0.908, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.00 (p 0.990, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.01 (p 0.969, n 18). could be the mix.
- skeptic
- leave-one-out range -0.10 to +0.12, sign flips 4; without severely affected donors +0.03 (p 0.908, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for STAT1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts