Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in fibro-adipogenic progenitors | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 3385
Sealed predictions
- STARD9 in oligodendrocytes, braak-0.61 (p 0.078) → -0.52 (p 0.155)receipt 3392
- STARD9 in dopamine neurons, braak-0.33 (p 0.389) → -0.50 (p 0.168)receipt 3393
Swarm cases
receipt 3393: STARD9 in dopamine neurons, braak
- power
- full sample -0.40 (p 0.097, n 18), 95% CI -0.73 to +0.08. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.075, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.075, n 18). could be the mix.
- skeptic
- leave-one-out range -0.51 to -0.34, sign flips 0; without severely affected donors -0.40 (p 0.097, n 18). robust.
- cell type
- strongest in oligodendrocytes: -0.59 (p 0.0096, n 18) vs -0.40 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for STARD9 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up STARD9 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.85 p 0.0025 (needs p < 5.4e-4)
receipt 3392: STARD9 in oligodendrocytes, braak
- power
- full sample -0.59 (p 0.0096, n 18), 95% CI -0.83 to -0.17. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.55 (p 0.018, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.61 (p 0.0069, n 18). not the mix.
- skeptic
- leave-one-out range -0.72 to -0.53, sign flips 0; without severely affected donors -0.59 (p 0.0096, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for STARD9 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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