parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 83	0.85
pathways Reactome	2 pathways; mostly energy	0.60

No case: the score is under the bar. Receipt 9320

ST8SIA4 in dopamine neurons, braak+0.20 (p 0.607) → +0.09 (p 0.820)receipt 9328
ST8SIA4 in microglia, braak+0.11 (p 0.775) → +0.50 (p 0.172)receipt 9327

receipt 9328: ST8SIA4 in dopamine neurons, braak

power: full sample +0.16 (p 0.538, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.690, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.12 (p 0.627, n 18). could be the mix.
skeptic: leave-one-out range +0.03 to +0.31, sign flips 0; without severely affected donors +0.16 (p 0.538, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ST8SIA4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9327: ST8SIA4 in microglia, braak

power: full sample +0.35 (p 0.150, n 18), 95% CI -0.14 to +0.70. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.35 (p 0.150, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.40 (p 0.103, n 18). could be the mix.
skeptic: leave-one-out range +0.27 to +0.53, sign flips 0; without severely affected donors +0.35 (p 0.150, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ST8SIA4 in microglia.

case closed: nothing better to follow up.

loading the receipts