Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: ask-8007 | 0.81 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 14 Parkinson's papers of 4,001 | 0.64 |
| pathways Reactome | 7 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 3060
Sealed predictions
- SPP1 in dopamine neurons, braak+0.04 (p 0.909) → +0.71 (p 0.032)receipt 3067
In the sealed studies
- An antigen-presenting microglial response: did not hold
Swarm cases
receipt 3067: SPP1 in dopamine neurons, braak
- power
- full sample +0.34 (p 0.161, n 18), 95% CI -0.15 to +0.70. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.33 (p 0.179, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.40 (p 0.097, n 18). could be the mix.
- skeptic
- leave-one-out range +0.26 to +0.49, sign flips 0; without severely affected donors +0.34 (p 0.161, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SPP1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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