Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in proximal tubule cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 44 | 0.85 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 8316
Sealed predictions
- SPNS1 in microglia, braakn/a → n/areceipt 8322
- SPNS1 in dopamine neurons, braak+0.25 (p 0.517) → -0.15 (p 0.706)receipt 8323
Swarm cases
receipt 8323: SPNS1 in dopamine neurons, braak
- power
- full sample +0.07 (p 0.794, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.06 (p 0.827, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.814, n 18). could be the mix.
- skeptic
- leave-one-out range -0.08 to +0.16, sign flips 2; without severely affected donors +0.07 (p 0.794, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SPNS1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 8322: SPNS1 in microglia, braak
- cell type
- SPNS1 is not measured in microglia; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SPNS1 in microglia.
case closed: nothing better to follow up.
Receipts
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