parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.08 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in podocytes	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	98 Parkinson's papers of 12,592	0.40
pathways Reactome	12 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 3240

receipt 3248: SOX2 in dopamine neurons, braak

power: full sample +0.05 (p 0.840, n 18), 95% CI -0.43 to +0.51. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.05 (p 0.847, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.16 (p 0.526, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.17, sign flips 3; without severely affected donors +0.05 (p 0.840, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SOX2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3247: SOX2 in astrocytes, braak

power: full sample +0.02 (p 0.928, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.14 (p 0.585, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.02 (p 0.935, n 18). could be the mix.
skeptic: leave-one-out range -0.10 to +0.14, sign flips 6; without severely affected donors +0.02 (p 0.928, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SOX2 in astrocytes.

case closed: nothing better to follow up.

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