Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.55 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 42 Parkinson's papers of 374 | 0.51 |
| pathways Reactome | 2 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 11461
Earlier readings: 2026-10-26 0.46; 2026-10-25 0.46; 2026-10-24 0.46; 2026-10-23 0.46.
Sealed predictions
- SMPD1 in dopamine neurons, braak+0.52 (p 0.152) → -0.45 (p 0.227)receipt 0588
- SMPD1 in dopamine neurons, braakn/a → n/areceipt 0130
- SMPD1 in dopamine neurons, resiliencen/a → n/areceipt 0131
Swarm cases
receipt 0588: SMPD1 in dopamine neurons, braak
- power
- full sample -0.09 (p 0.735, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.11 (p 0.677, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.640, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.02, sign flips 2; without severely affected donors -0.09 (p 0.735, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SMPD1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0131: SMPD1 in dopamine neurons, resilience
- cell type
- SMPD1 is not measured in dopamine neurons; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for SMPD1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0130: SMPD1 in dopamine neurons, braak
- cell type
- SMPD1 is not measured in dopamine neurons; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SMPD1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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