parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.09 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in astrocytes (424 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	55 Parkinson's papers of 4,744	0.47
pathways Reactome	3 pathways; mostly iron and oxidative stress	0.80

No case: the score is under the bar. Receipt 2805

SLC7A11 in astrocytes, braak+0.05 (p 0.893) → +0.58 (p 0.102)receipt 2809
SLC7A11 in dopamine neurons, braak+0.30 (p 0.428) → +0.03 (p 0.946)receipt 2810

receipt 2810: SLC7A11 in dopamine neurons, braak

power: full sample +0.18 (p 0.482, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.17 (p 0.493, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.19 (p 0.455, n 18). could be the mix.
skeptic: leave-one-out range +0.10 to +0.33, sign flips 0; without severely affected donors +0.18 (p 0.482, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SLC7A11 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2809: SLC7A11 in astrocytes, braak

power: full sample +0.26 (p 0.289, n 18), 95% CI -0.23 to +0.65. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.24 (p 0.332, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.39 (p 0.107, n 18). could be the mix.
skeptic: leave-one-out range +0.16 to +0.39, sign flips 0; without severely affected donors +0.26 (p 0.289, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SLC7A11 in astrocytes.

case closed: nothing better to follow up.

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