Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.13 (overall 0.08) | 0.13 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (enterocytes) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3275
Sealed predictions
- SLC5A9 in dopamine neurons, braak-0.01 (p 0.982) → -0.78 (p 0.013)receipt 3282
Swarm cases
receipt 3282: SLC5A9 in dopamine neurons, braak
- power
- full sample -0.44 (p 0.067, n 18), 95% CI -0.75 to +0.03. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.46 (p 0.055, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.66 (p 0.0026, n 18). not the mix.
- skeptic
- leave-one-out range -0.54 to -0.37, sign flips 0; without severely affected donors -0.44 (p 0.067, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC5A9 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts