Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in hepatocytes | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 47 Parkinson's papers of 159 | 0.49 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6492
Sealed predictions
- SLC30A10 in dopamine neurons, braak+0.84 (p 0.004) → +0.37 (p 0.329)receipt 6500
- SLC30A10 in astrocytes, braak-0.16 (p 0.685) → -0.30 (p 0.436)receipt 6499
Swarm cases
receipt 6500: SLC30A10 in dopamine neurons, braak
- power
- full sample +0.68 (p 0.0019, n 18), 95% CI +0.31 to +0.87. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.70 (p 0.0012, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.68 (p 0.0021, n 18). not the mix.
- skeptic
- leave-one-out range +0.64 to +0.79, sign flips 0; without severely affected donors +0.68 (p 0.0019, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC30A10 in dopamine neurons.
case closed: nothing better to follow up.
receipt 6499: SLC30A10 in astrocytes, braak
- power
- full sample -0.12 (p 0.640, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.10 (p 0.702, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.12 (p 0.646, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to +0.01, sign flips 1; without severely affected donors -0.12 (p 0.640, n 18). fragile.
- cell type
- strongest in dopamine neurons: +0.68 (p 0.0019, n 18) vs -0.12 in astrocytes. proposing dopamine neurons.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC30A10 in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SLC30A10 · dopamine neurons · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.38 p 0.183 (needs p < 3.2e-4)
Receipts
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