Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in proximal tubule cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | PubMed did not answer (PubMed: HTTP 500) | 0.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 17069
Sealed predictions
- SLC25A48 in astrocytes, braak-0.27 (p 0.487) → -0.15 (p 0.705)receipt 17076
- SLC25A48 in dopamine neurons, braak-0.04 (p 0.926) → -0.26 (p 0.504)receipt 17077
Swarm cases
receipt 17077: SLC25A48 in dopamine neurons, braak
- power
- full sample -0.39 (p 0.107, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.107, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.59 (p 0.011, n 18). not the mix.
- skeptic
- leave-one-out range -0.56 to -0.32, sign flips 0; without severely affected donors -0.39 (p 0.107, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC25A48 in dopamine neurons.
case closed: nothing better to follow up.
receipt 17076: SLC25A48 in astrocytes, braak
- power
- full sample -0.24 (p 0.341, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.487, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.14 (p 0.573, n 18). could be the mix.
- skeptic
- leave-one-out range -0.42 to -0.17, sign flips 0; without severely affected donors -0.24 (p 0.341, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC25A48 in astrocytes.
case closed: nothing better to follow up.
Receipts
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