Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (9 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 60 | 0.82 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 11348
Sealed predictions
- SLC18A1 in dopamine neurons, braak-0.04 (p 0.924) → +0.03 (p 0.946)receipt 11355
Swarm cases
receipt 11355: SLC18A1 in dopamine neurons, braak
- power
- full sample +0.02 (p 0.935, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.983, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.861, n 18). could be the mix.
- skeptic
- leave-one-out range -0.09 to +0.15, sign flips 5; without severely affected donors +0.02 (p 0.935, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC18A1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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