Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.28 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in mucous neck cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1451
Sealed predictions
- SLC12A2 in dopamine neurons, braak+0.04 (p 0.912) → -0.22 (p 0.565)receipt 1459
- SLC12A2 in oligodendrocytes, braak+0.24 (p 0.529) → +0.27 (p 0.487)receipt 1458
Swarm cases
receipt 1459: SLC12A2 in dopamine neurons, braak
- power
- full sample -0.13 (p 0.597, n 18), 95% CI -0.57 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.398, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.640, n 18). could be the mix.
- skeptic
- leave-one-out range -0.29 to -0.02, sign flips 0; without severely affected donors -0.13 (p 0.597, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC12A2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 1458: SLC12A2 in oligodendrocytes, braak
- power
- full sample +0.19 (p 0.450, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.455, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.25 (p 0.310, n 18). could be the mix.
- skeptic
- leave-one-out range +0.09 to +0.32, sign flips 0; without severely affected donors +0.19 (p 0.450, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC12A2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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