Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 9 Parkinson's papers of 4,275 | 0.70 |
| pathways Reactome | 2 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 13741
Sealed predictions
- SKI in dopamine neurons, braak-0.42 (p 0.262) → -0.54 (p 0.136)receipt 13748
Swarm cases
receipt 13748: SKI in dopamine neurons, braak
- power
- full sample -0.52 (p 0.026, n 18), 95% CI -0.80 to -0.07. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.51 (p 0.030, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.73 (p 5.3e-4, n 18). not the mix.
- skeptic
- leave-one-out range -0.62 to -0.46, sign flips 0; without severely affected donors -0.52 (p 0.026, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SKI in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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