Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.12 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: srt-2104 | 0.90 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 333 Parkinson's papers of 18,000 | 0.23 |
| pathways Reactome | 9 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 2349
Sealed predictions
- SIRT1 in dopamine neurons, braak+0.47 (p 0.204) → -0.03 (p 0.946)receipt 2356
Swarm cases
receipt 2356: SIRT1 in dopamine neurons, braak
- power
- full sample +0.16 (p 0.538, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.450, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.337, n 18). could be the mix.
- skeptic
- leave-one-out range +0.05 to +0.29, sign flips 0; without severely affected donors +0.16 (p 0.538, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SIRT1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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