Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (kupffer cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 346 | 0.82 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 4886
Sealed predictions
- SIGLEC1 in dopamine neurons, braak+0.10 (p 0.802) → -0.44 (p 0.232)receipt 4894
Swarm cases
receipt 4894: SIGLEC1 in dopamine neurons, braak
- power
- full sample -0.25 (p 0.315, n 18), 95% CI -0.64 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.323, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.105, n 18). could be the mix.
- skeptic
- leave-one-out range -0.38 to -0.16, sign flips 0; without severely affected donors -0.25 (p 0.315, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SIGLEC1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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