Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.05 (overall 0.03) | 0.05 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in adipocytes | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 6867
Sealed predictions
- SHISA6 in dopamine neurons, braak-0.11 (p 0.785) → +0.04 (p 0.909)receipt 6874
Swarm cases
receipt 6874: SHISA6 in dopamine neurons, braak
- power
- full sample -0.05 (p 0.854, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.00 (p 0.997, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.17 (p 0.498, n 18). could be the mix.
- skeptic
- leave-one-out range -0.13 to +0.07, sign flips 3; without severely affected donors -0.05 (p 0.854, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SHISA6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts