Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 178 | 0.76 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4619
Sealed predictions
- SHANK1 in dopamine neurons, braak-0.46 (p 0.212) → -0.01 (p 0.982)receipt 4627
Swarm cases
receipt 4627: SHANK1 in dopamine neurons, braak
- power
- full sample -0.26 (p 0.302, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.28 (p 0.261, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.035, n 18). not the mix.
- skeptic
- leave-one-out range -0.37 to -0.16, sign flips 0; without severely affected donors -0.26 (p 0.302, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SHANK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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