Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (alveolar cells type 2) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 4 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 9670
Sealed predictions
- SFTPB in dopamine neurons, braak-0.24 (p 0.533) → -0.80 (p 0.010)receipt 9677
Swarm cases
receipt 9677: SFTPB in dopamine neurons, braak
- power
- full sample -0.55 (p 0.017, n 18), 95% CI -0.81 to -0.12. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.60 (p 0.0086, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.64 (p 0.0044, n 18). not the mix.
- skeptic
- leave-one-out range -0.67 to -0.50, sign flips 0; without severely affected donors -0.55 (p 0.017, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SFTPB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts