Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: aleplasinin | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 1,650 | 0.82 |
| pathways Reactome | 9 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3186
Sealed predictions
- SERPINE1 in dopamine neurons, braak-0.66 (p 0.053) → -0.22 (p 0.576)receipt 3193
Swarm cases
receipt 3193: SERPINE1 in dopamine neurons, braak
- power
- full sample -0.46 (p 0.055, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.46 (p 0.055, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.018, n 18). not the mix.
- skeptic
- leave-one-out range -0.62 to -0.39, sign flips 0; without severely affected donors -0.46 (p 0.055, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SERPINE1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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