Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in syncytiotrophoblasts | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 160 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10037
Sealed predictions
- SEMA6A in dopamine neurons, braak-0.13 (p 0.735) → +0.24 (p 0.530)receipt 10046
- SEMA6A in oligodendrocytes, braak-0.17 (p 0.666) → +0.46 (p 0.217)receipt 10045
Swarm cases
receipt 10046: SEMA6A in dopamine neurons, braak
- power
- full sample +0.03 (p 0.908, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.02 (p 0.928, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.888, n 18). could be the mix.
- skeptic
- leave-one-out range -0.07 to +0.16, sign flips 7; without severely affected donors +0.03 (p 0.908, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SEMA6A in dopamine neurons.
case closed: nothing better to follow up.
receipt 10045: SEMA6A in oligodendrocytes, braak
- power
- full sample +0.19 (p 0.460, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.487, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.15 (p 0.561, n 18). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.33, sign flips 0; without severely affected donors +0.19 (p 0.460, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SEMA6A in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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