Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in podocytes | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 9 Parkinson's papers of 150 | 0.70 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6119
Sealed predictions
- SEMA5A in dopamine neurons, braak-0.29 (p 0.443) → +0.00 (p 1.000)receipt 6127
- SEMA5A in oligodendrocytes, braak-0.31 (p 0.414) → +0.27 (p 0.485)receipt 6126
Swarm cases
receipt 6127: SEMA5A in dopamine neurons, braak
- power
- full sample -0.16 (p 0.515, n 18), 95% CI -0.59 to +0.33. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.14 (p 0.585, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.099, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.05, sign flips 0; without severely affected donors -0.16 (p 0.515, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SEMA5A in dopamine neurons.
case closed: nothing better to follow up.
receipt 6126: SEMA5A in oligodendrocytes, braak
- power
- full sample -0.10 (p 0.696, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.10 (p 0.696, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
- skeptic
- leave-one-out range -0.21 to +0.01, sign flips 2; without severely affected donors -0.10 (p 0.696, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SEMA5A in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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