Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.52 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (late spermatids) | 0.10 |
| chemistry Open Targets | compounds already reach it: nktr-171, tetracaine, dronedarone hydrochloride +73 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 283 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0193
Sealed predictions
- SCN10A in dopamine neurons, braak+0.71 (p 0.032) → -0.23 (p 0.549)receipt 0199
Swarm cases
receipt 0199: SCN10A in dopamine neurons, braak
- power
- full sample +0.16 (p 0.515, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.555, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.15 (p 0.549, n 18). could be the mix.
- skeptic
- leave-one-out range +0.07 to +0.31, sign flips 0; without severely affected donors +0.16 (p 0.515, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SCN10A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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