Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

SACK1B

scaffolding CK1 anchoring protein B

translation score 0.45, read 2026-10-23; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.02 from other evidence0.00
cell type
Human Protein Atlas
not in the Protein Atlas0.00
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
4 pathways; mostly growth signalling0.60

No case: the score is under the bar. Receipt 7967

Sealed predictions

  1. SACK1B in dopamine neurons, braakn/a → n/areceipt 7974

Swarm cases

receipt 7974: SACK1B in dopamine neurons, braak

cell type
SACK1B is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SACK1B in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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