Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: sar-407899, fasudil, verosudil +10 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 8 Parkinson's papers of 2,128 | 0.71 |
| pathways Reactome | 15 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3619
Sealed predictions
- ROCK1 in dopamine neurons, braak-0.47 (p 0.197) → +0.66 (p 0.054)receipt 3626
Swarm cases
receipt 3626: ROCK1 in dopamine neurons, braak
- power
- full sample +0.19 (p 0.439, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.544, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.355, n 18). could be the mix.
- skeptic
- leave-one-out range +0.09 to +0.35, sign flips 0; without severely affected donors +0.19 (p 0.439, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ROCK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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