Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in lactotrophs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 780 | 0.79 |
| pathways Reactome | 9 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 12017
Sealed predictions
- ROBO1 in dopamine neurons, braak+0.19 (p 0.631) → +0.94 (p 2.1e-4)receipt 12025
Swarm cases
receipt 12025: ROBO1 in dopamine neurons, braak
- power
- full sample +0.52 (p 0.026, n 18), 95% CI +0.07 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.52 (p 0.027, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.52 (p 0.026, n 18). not the mix.
- skeptic
- leave-one-out range +0.47 to +0.71, sign flips 0; without severely affected donors +0.52 (p 0.026, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ROBO1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts