parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (4 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	39 Parkinson's papers of 2,582	0.52
pathways Reactome	11 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 7452

receipt 7460: RIPK3 in dopamine neurons, braak

power: full sample -0.39 (p 0.111, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.44 (p 0.067, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.087, n 18). could be the mix.
skeptic: leave-one-out range -0.55 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.111, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RIPK3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7459: RIPK3 in microglia, braak

power: full sample -0.05 (p 0.840, n 18), 95% CI -0.51 to +0.43. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.01 (p 0.983, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.02 (p 0.935, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.10, sign flips 2; without severely affected donors -0.05 (p 0.840, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RIPK3 in microglia.

case closed: nothing better to follow up.

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