Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.44 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: gsk2982772 | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 55 Parkinson's papers of 2,807 | 0.47 |
| pathways Reactome | 24 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 0446
Sealed predictions
- RIPK1 in dopamine neurons, braak+0.22 (p 0.563) → -0.50 (p 0.168)receipt 0453
Swarm cases
receipt 0453: RIPK1 in dopamine neurons, braak
- power
- full sample -0.12 (p 0.649, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.14 (p 0.567, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.06 (p 0.820, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.02, sign flips 1; without severely affected donors -0.12 (p 0.649, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RIPK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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