Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

RIGI

RNA sensor RIG-I

translation score 0.60, read 2026-10-29; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced in microglia (62 nCPM)1.00
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		4 Parkinson's papers of 3,3890.79
pathways
Reactome		15 pathways; mostly immune signalling0.90
proposal for RIGI, translation score 0.60

Knock down and overexpress RIGI in microglia; measure IL-1β and TNF release and surface HLA-DR and uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release).

Cell type
microglia
Direction
Both arms: public data does not say which way helps.
Molecular readout
IL-1β and TNF release and surface HLA-DR
Functional readout
uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release)
Rule-out
If neither arm moves IL-1β by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of RIGI in iPSC-derived microglia (iMGL); n = 3 differentiations; readouts: IL-1β and TNF release and surface HLA-DR; uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release). Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. RIGI in microglia, braakn/a → n/areceipt 13570
  2. RIGI in dopamine neurons, braakn/a → n/areceipt 13571

Swarm cases

receipt 13571: RIGI in dopamine neurons, braak

cell type
RIGI is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RIGI in dopamine neurons.

case closed: nothing better to follow up.

receipt 13570: RIGI in microglia, braak

cell type
RIGI is not measured in microglia; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RIGI in microglia.

case closed: nothing better to follow up.

Receipts

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