parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (108 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	1 Parkinson's trial, 0 stopped	1.00
literature PubMed	44 Parkinson's papers of 13,616	0.50
pathways Reactome	26 pathways; mostly growth signalling	0.60

No case: the score is under the bar. Receipt 6298

receipt 6306: RHOA in dopamine neurons, braak

power: full sample +0.28 (p 0.254, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.35 (p 0.156, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.069, n 18). could be the mix.
skeptic: leave-one-out range +0.19 to +0.39, sign flips 0; without severely affected donors +0.28 (p 0.254, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RHOA in dopamine neurons.

case closed: nothing better to follow up.

receipt 6305: RHOA in microglia, braak

power: full sample -0.07 (p 0.787, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.18 (p 0.471, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.10 (p 0.702, n 18). could be the mix.
skeptic: leave-one-out range -0.16 to +0.07, sign flips 3; without severely affected donors -0.07 (p 0.787, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RHOA in microglia.

case closed: nothing better to follow up.

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