parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.04 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in vascular smooth muscle cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	5 Parkinson's papers of 143	0.76
pathways Reactome	2 pathways; mostly protein handling	0.90

No case: the score is under the bar. Receipt 6134

receipt 6142: RGS6 in dopamine neurons, braak

power: full sample +0.01 (p 0.983, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.05 (p 0.834, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.07 (p 0.781, n 18). could be the mix.
skeptic: leave-one-out range -0.14 to +0.10, sign flips 9; without severely affected donors +0.01 (p 0.983, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RGS6 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6141: RGS6 in astrocytes, braak

power: full sample +0.11 (p 0.652, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.702, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.10 (p 0.702, n 18). could be the mix.
skeptic: leave-one-out range -0.02 to +0.21, sign flips 1; without severely affected donors +0.11 (p 0.652, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RGS6 in astrocytes.

case closed: nothing better to follow up.

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