Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 1 stopped | 0.84 |
| literature PubMed | 82 Parkinson's papers of 19,251 | 0.42 |
| pathways Reactome | 8 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15061
Sealed predictions
- RAN in dopamine neurons, braak+0.43 (p 0.243) → -0.21 (p 0.581)receipt 15068
Swarm cases
receipt 15068: RAN in dopamine neurons, braak
- power
- full sample +0.11 (p 0.664, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.677, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.310, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.24, sign flips 2; without severely affected donors +0.11 (p 0.664, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAN in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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