Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: belvarafenib, ly-3009120, xl-281 +6 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 4,144 | 0.71 |
| pathways Reactome | 17 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 6260
Sealed predictions
- RAF1 in dopamine neurons, braak+0.30 (p 0.428) → +0.69 (p 0.041)receipt 6268
Swarm cases
receipt 6268: RAF1 in dopamine neurons, braak
- power
- full sample +0.35 (p 0.159, n 18), 95% CI -0.14 to +0.70. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.41 (p 0.087, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.156, n 18). could be the mix.
- skeptic
- leave-one-out range +0.26 to +0.46, sign flips 0; without severely affected donors +0.35 (p 0.159, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAF1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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