Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 63 Parkinson's papers of 314 | 0.45 |
| pathways Reactome | 7 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 5599
Sealed predictions
- RAB8A in dopamine neurons, braak-0.11 (p 0.784) → -0.06 (p 0.888)receipt 5605
Swarm cases
receipt 5605: RAB8A in dopamine neurons, braak
- power
- full sample -0.03 (p 0.894, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.03 (p 0.894, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.02 (p 0.928, n 18). could be the mix.
- skeptic
- leave-one-out range -0.16 to +0.09, sign flips 6; without severely affected donors -0.03 (p 0.894, n 18). fragile.
- cell type
- strongest in microglia: -0.71 (p 9.1e-4, n 18) vs -0.03 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAB8A in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up RAB8A · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.00 p 1.000 (needs p < 3.6e-4)
Receipts
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