parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	group enriched, including oligodendrocytes; strongest in epicardial cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 19	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 9368

receipt 9376: RAB6C in dopamine neurons, braak

power: full sample -0.16 (p 0.515, n 18), 95% CI -0.59 to +0.33. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.14 (p 0.591, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.13 (p 0.609, n 18). could be the mix.
skeptic: leave-one-out range -0.31 to -0.08, sign flips 0; without severely affected donors -0.16 (p 0.515, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RAB6C in dopamine neurons.

case closed: nothing better to follow up.

receipt 9375: RAB6C in oligodendrocytes, braak

power: full sample +0.11 (p 0.652, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.11 (p 0.664, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.03 (p 0.915, n 18). could be the mix.
skeptic: leave-one-out range +0.00 to +0.26, sign flips 0; without severely affected donors +0.11 (p 0.652, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RAB6C in oligodendrocytes.

case closed: nothing better to follow up.

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