Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 12 Parkinson's papers of 431 | 0.66 |
| pathways Reactome | 8 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 7634
Sealed predictions
- RAB5A in dopamine neurons, braak-0.11 (p 0.787) → +0.63 (p 0.068)receipt 7642
Swarm cases
receipt 7642: RAB5A in dopamine neurons, braak
- power
- full sample +0.40 (p 0.097, n 18), 95% CI -0.08 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.43 (p 0.077, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.156, n 18). could be the mix.
- skeptic
- leave-one-out range +0.33 to +0.54, sign flips 0; without severely affected donors +0.40 (p 0.097, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAB5A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts