Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including other brain neurons; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 29 Parkinson's papers of 692 | 0.55 |
| pathways Reactome | 10 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 5631
Sealed predictions
- RAB3A in dopamine neurons, braak-0.34 (p 0.369) → -0.44 (p 0.234)receipt 5638
Swarm cases
receipt 5638: RAB3A in dopamine neurons, braak
- power
- full sample -0.42 (p 0.084, n 18), 95% CI -0.74 to +0.06. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.51 (p 0.032, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.60 (p 0.0089, n 18). not the mix.
- skeptic
- leave-one-out range -0.53 to -0.35, sign flips 0; without severely affected donors -0.42 (p 0.084, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAB3A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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