Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (melanocytes) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 7 Parkinson's papers of 132 | 0.73 |
| pathways Reactome | 2 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 6435
Sealed predictions
- RAB38 in dopamine neurons, braak+0.18 (p 0.646) → +0.74 (p 0.024)receipt 6443
Swarm cases
receipt 6443: RAB38 in dopamine neurons, braak
- power
- full sample +0.43 (p 0.079, n 18), 95% CI -0.05 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.45 (p 0.063, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.042, n 18). not the mix.
- skeptic
- leave-one-out range +0.34 to +0.62, sign flips 0; without severely affected donors +0.43 (p 0.079, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAB38 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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