Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (retinal horizontal cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 274 | 0.79 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6405
Sealed predictions
- PVALB in dopamine neurons, braak+0.26 (p 0.502) → -0.17 (p 0.671)receipt 6412
Swarm cases
receipt 6412: PVALB in dopamine neurons, braak
- power
- full sample +0.02 (p 0.935, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.05 (p 0.840, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.956, n 18). could be the mix.
- skeptic
- leave-one-out range -0.12 to +0.13, sign flips 6; without severely affected donors +0.02 (p 0.935, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PVALB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts