parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.37 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	4 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 0807

receipt 0814: PTPRJ in dopamine neurons, braak

power: full sample -0.53 (p 0.024, n 18), 95% CI -0.80 to -0.08. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.57 (p 0.013, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.59 (p 0.011, n 18). not the mix.
skeptic: leave-one-out range -0.64 to -0.47, sign flips 0; without severely affected donors -0.53 (p 0.024, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PTPRJ in dopamine neurons.

case closed: nothing better to follow up.

receipt 0813: PTPRJ in microglia, braak

power: full sample -0.11 (p 0.677, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.728, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.09 (p 0.715, n 18). could be the mix.
skeptic: leave-one-out range -0.27 to -0.01, sign flips 0; without severely affected donors -0.11 (p 0.677, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PTPRJ in microglia.

case closed: nothing better to follow up.

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