Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: cal | 0.81 |
| trials ClinicalTrials.gov | 14 Parkinson's trials, 1 stopped | 0.94 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11979
Sealed predictions
- PTHLH in dopamine neurons, braak+0.74 (p 0.023) → -0.15 (p 0.702)receipt 11986
Swarm cases
receipt 11986: PTHLH in dopamine neurons, braak
- power
- full sample +0.22 (p 0.379, n 18), 95% CI -0.27 to +0.62. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.31 (p 0.218, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.173, n 18). could be the mix.
- skeptic
- leave-one-out range +0.10 to +0.31, sign flips 0; without severely affected donors +0.22 (p 0.379, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PTHLH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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