Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PTGER1

prostaglandin E receptor 1

translation score 0.46, read 2026-10-30; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (renal collecting duct principal cells)0.10
chemistry
Open Targets
compounds already reach it: dinoprostone, alprostadil, ono-85391.00
trials
ClinicalTrials.gov
6 Parkinson's trials, 1 stopped0.87
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 14603

Sealed predictions

  1. PTGER1 in dopamine neurons, braakn/a → n/areceipt 14610

Swarm cases

receipt 14610: PTGER1 in dopamine neurons, braak

cell type
PTGER1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PTGER1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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