Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: bortezomib d-mannitol, carfilzomib, marizomib +4 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 11 Parkinson's papers of 374 | 0.67 |
| pathways Reactome | 5 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 2984
Sealed predictions
- PSMB8 in dopamine neurons, braak-0.23 (p 0.560) → +0.17 (p 0.663)receipt 2991
Swarm cases
receipt 2991: PSMB8 in dopamine neurons, braak
- power
- full sample -0.08 (p 0.754, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.05 (p 0.847, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.05 (p 0.834, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.07, sign flips 3; without severely affected donors -0.08 (p 0.754, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PSMB8 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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