Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (syncytiotrophoblasts) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 136 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15610
Sealed predictions
- PSG1 in dopamine neurons, braak-0.13 (p 0.732) → -0.33 (p 0.389)receipt 15618
Swarm cases
receipt 15618: PSG1 in dopamine neurons, braak
- power
- full sample -0.10 (p 0.690, n 18), 95% CI -0.54 to +0.38. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.976, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.365, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.01, sign flips 2; without severely affected donors -0.10 (p 0.690, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PSG1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts