Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.26 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: begacestat, rg-4733, nirogacestat hydrobromide +4 | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 72 | 0.91 |
| pathways Reactome | 13 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 1587
Sealed predictions
- PSENEN in dopamine neurons, braak-0.12 (p 0.756) → -0.43 (p 0.251)receipt 1625
Swarm cases
receipt 1625: PSENEN in dopamine neurons, braak
- power
- full sample -0.26 (p 0.302, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.369, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.20 (p 0.418, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.14, sign flips 0; without severely affected donors -0.26 (p 0.302, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PSENEN in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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