Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 93 | 0.91 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7769
Sealed predictions
- PRSS3 in dopamine neurons, braak-0.26 (p 0.504) → -0.40 (p 0.285)receipt 7776
Swarm cases
receipt 7776: PRSS3 in dopamine neurons, braak
- power
- full sample -0.29 (p 0.239, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.33 (p 0.182, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.218, n 18). could be the mix.
- skeptic
- leave-one-out range -0.42 to -0.19, sign flips 0; without severely affected donors -0.29 (p 0.239, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRSS3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts